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Man's Search for Medicine

Brandon Smith and Zach Pope

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Man's Search for Medicine
Man's Search for Medicine

Man's Search for Medicine

Brandon Smith and Zach Pope

1
Followers
0
Plays
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About Us

Two medical students at the University of Tennessee seek the education not provided by medical school. With a healthy dose of skepticism and curiosity, they shed light on the best practices for preventing illness, optimizing health, and improving the standard-of-care for chronic disease.

Latest Episodes

#002: "What's the point of intermittent fasting?"

Brandon and Zach share their experiences with intermittent fasting and discuss the physiology and potential as medical therapy. Subjective: 0:58 - Catching up on clinical rotations and recent events 11:08 - Intermittent fasting definitions, terminology, and background 16:45 - Brandon and Zach’s personal fasting habits, 24:22 - What’s the “80/20” for eating and nutrition? 27:00 - The history of fasting across cultures 29:20 - What was the result of a 382-day fast? Objective: 32:25 - Overview of fasting physiology: glucose regulation, ketone production, epinephrine, HGH 39:02 - Calorie-restriction v. intermittent fasting 42:45 - What breaks a fast? 44:55 - Autophagy and mTOR in fasting Assessment/Plan: 49:40 - Risks and adverse side effects: hypoglycemia, orthorexia, refeeding syndrome 54:50 - Conclusion, future directions People, Books, Podcasts Mentioned: FoundMyFitness Podcast - Rhonda Patrick, Ph.D. “Wired to Eat” Robb Wolf Dr. Valter Longo, Ph.D. Dr. Jason Fung, M.D. Dr. Pe...

57 MINMAR 15
Comments
#002: "What's the point of intermittent fasting?"

#001: "Should I be taking a probiotic?"

Zach and Brandon discuss the evidence for and against using probiotics as treatment for medical diseases and the mechanisms that may confer health benefits to individuals without disease. Subjective: 0:45 - Brandon’s experience at the Metabolic Health Summit 10:19 - Introduction to probiotics 21:38 - Zach and Brandon’s probiotic protocol for themselves 24:25 - Introduction to the microbiome Objective: 32:25 - Probiotics as treatment and prevention for type II diabetes and obesity 45:08 - Treating digestive diseases with probiotics 55:20 - Using probiotics to treat and prevent allergic rhinitis and eczema 57:08 - Probiotics and depression 1:01:06 - Short-chain fatty acid (SCFA) effects on inflammation and innate immunity 1:18:00 - SCFAs and the gut-brain axis 1:24:34 - Insulin and satiety regulation through SCFAs 1:30:45 - Mitigating antibiotic side effects 1:32:30 - What to look for: strains, dosage, viability, timing 1:40:10 - Safety concerns and side effects Assessment/Plan: 1:4...

107 MINFEB 11
Comments
#001: "Should I be taking a probiotic?"

#000: An Introduction

Zach and Brandon introduce themselves and share their intentions and expectations for the podcast.

12 MINFEB 4
Comments
#000: An Introduction
the END

Latest Episodes

#002: "What's the point of intermittent fasting?"

Brandon and Zach share their experiences with intermittent fasting and discuss the physiology and potential as medical therapy. Subjective: 0:58 - Catching up on clinical rotations and recent events 11:08 - Intermittent fasting definitions, terminology, and background 16:45 - Brandon and Zach’s personal fasting habits, 24:22 - What’s the “80/20” for eating and nutrition? 27:00 - The history of fasting across cultures 29:20 - What was the result of a 382-day fast? Objective: 32:25 - Overview of fasting physiology: glucose regulation, ketone production, epinephrine, HGH 39:02 - Calorie-restriction v. intermittent fasting 42:45 - What breaks a fast? 44:55 - Autophagy and mTOR in fasting Assessment/Plan: 49:40 - Risks and adverse side effects: hypoglycemia, orthorexia, refeeding syndrome 54:50 - Conclusion, future directions People, Books, Podcasts Mentioned: FoundMyFitness Podcast - Rhonda Patrick, Ph.D. “Wired to Eat” Robb Wolf Dr. Valter Longo, Ph.D. Dr. Jason Fung, M.D. Dr. Pe...

57 MINMAR 15
Comments
#002: "What's the point of intermittent fasting?"

#001: "Should I be taking a probiotic?"

Zach and Brandon discuss the evidence for and against using probiotics as treatment for medical diseases and the mechanisms that may confer health benefits to individuals without disease. Subjective: 0:45 - Brandon’s experience at the Metabolic Health Summit 10:19 - Introduction to probiotics 21:38 - Zach and Brandon’s probiotic protocol for themselves 24:25 - Introduction to the microbiome Objective: 32:25 - Probiotics as treatment and prevention for type II diabetes and obesity 45:08 - Treating digestive diseases with probiotics 55:20 - Using probiotics to treat and prevent allergic rhinitis and eczema 57:08 - Probiotics and depression 1:01:06 - Short-chain fatty acid (SCFA) effects on inflammation and innate immunity 1:18:00 - SCFAs and the gut-brain axis 1:24:34 - Insulin and satiety regulation through SCFAs 1:30:45 - Mitigating antibiotic side effects 1:32:30 - What to look for: strains, dosage, viability, timing 1:40:10 - Safety concerns and side effects Assessment/Plan: 1:4...

107 MINFEB 11
Comments
#001: "Should I be taking a probiotic?"

#000: An Introduction

Zach and Brandon introduce themselves and share their intentions and expectations for the podcast.

12 MINFEB 4
Comments
#000: An Introduction
the END