title

CVR podcast Contagious Thinking

MRC-University of Glasgow Centre for Virus Researc

1
Followers
3
Plays
CVR podcast Contagious Thinking
CVR podcast Contagious Thinking

CVR podcast Contagious Thinking

MRC-University of Glasgow Centre for Virus Researc

1
Followers
3
Plays
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About Us

What is a virus? How do they cause disease? What can we do to stop them? Find out here, in the podcast from the Medical Research Council (MRC)-University of Glasgow Centre for Virus Research (CVR), brought to you by our staff and students.

Latest Episodes

Robert J. Gifford: Sequence, Blast, rinse and repeat

In this final episode, we change gears, from innate immunity to virus biology and evolution. Today, postdocs Connor and Elihu talk with Dr. Robert Gifford, CVR’s resident evolutionary virologist and senior research fellow. Rob’s lab combines sequence data and software development to explore virus genomics and coevolution of viruses and their hosts. He applies virus genomics to help and guide treatment of HCV-infected patients; support genomic surveillance and outbreak response for bluetongue and rabies; and explore the diversity of endogenous viral elements in published genome sequence data, just to name a few of his projects. Listen to him tell us how he became interested in this paleovirology by starting out working on endogenous retroviruses at Imperial College long before the NGS metagenomics techniques come about. Thank you for listening to us, and thanks to Rob for joining us this episode. As always, you can find our previous content at https://cvrblog.myportfolio.com/, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog Join us next season with more new hosts and more contagious thinking. Featuring: Connor Bamford, Elihu Aranday-Cortes and Robert J. Gifford Editing: Elihu Aranday-Cortes Music: Inspire - Benjamin Tissot - www.bensound.com

62 MINMAR 26
Comments
Robert J. Gifford: Sequence, Blast, rinse and repeat

Marlene Dreux and the interferogenic synapse

Season 2 Episode 7: Today Connor's following on the theme of innate immunity started by Greg and Adam in the last two episodes and is joined by Dr Marlene Dreux, Team Leader in immunovirology at the Centre International de Recherche en Infectiologie (CIRI) in Lyon, France. Marlene combines cell biology, viruses and immunity to find out how our cells sense viral infections, like dengue, chikungunya and hepatitis C virus, to keep us safe. The Dreux lab very recently published a study identifying a new cell communication structure, the 'interferogenic synapse' that acts to block viral infection. See the pre-print here: https://www.biorxiv.org/content/10.1101/374496v1 Listen to her tell us how she became interested in this anti-arbovirus immunity by starting out working on HCV in France and then in the USA. You can find our previous content on antivirus immunity over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Join us next week when we're sticking looking at one of the CVR's own researchers, resident evolutionary virologist Dr Rob Gifford. Featuring: Connor Bamford & Marlene Dreux Editing: Connor Bamford Music: Inspire - Benjamin Tissot - www.bensound.com

15 MINMAR 18
Comments
Marlene Dreux and the interferogenic synapse

Biochemistry of innate immunity with Adam Fletcher

Season 2 Episode: 6 I hope you enjoyed last week’s episode with Jack, Douglas and Greg Towers because now we’re continuing on that theme and speaking with Dr Adam Fletcher, a fellow innate/intrinsic immunity enthusiast, like Greg. Adam (https://scholar.google.co.uk/citations?user=cEzmpPEAAAAJ&hl=en), has led work on fantastic papers onto the detailed molecular mechanisms that our cells use to seek, destroy and ultimate block disease-causing viruses, like HIV, from infecting us. One example if the very recent paper in Cell Host & Microbe https://www.sciencedirect.com/science/article/pii/S1931312818305456 (from which our cover image is from). Adam worked previously with Leo James at the Laboratory of Molecular Biology or LMB in Cambridge, and actually with Greg Towers at University College London. Adam is currently a postdoc working 'around the corner' from us here at in the CVR at the University of Dundee, MRC PPU. In this episode, Adam tells us about his work on antiviral immunity and what it is like being an early-career researcher in virology. As always, you can find our previous content on antiviral immunity over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog Join us next week, where we’ll be joined by Dr Marlene Dreux, who tell us some more about the antiviral immune response through the lens of cell biology. Featuring: Elihu Aranday-Cortes, Connor Bamford and Adam Fletcher. Editing: Connor Bamford Music: Inspire - Benjamin Tissot - www.bensound.com

17 MINMAR 11
Comments
Biochemistry of innate immunity with Adam Fletcher

How HIV Survives The Minefield - Prof Greg Towers

Season 2 Episode 5: Having heard about Dr Liz Wright's work with HIV and Cryo EM last week, this week Jack and Douglas take a deep dive into the HIV field with Professor Greg Towers. Having established a enduring interest in HIV virology at a young age, Prof. Towers and his lab - based at University College London - work on some of the fundamental questions of HIV virology, including trying to understand what the differences are between pandemic strains and non-pandemic strains of the virus. We chat with Greg about this work and about other aspects of HIV virology, including intrinsic immunity and HIV restriction, HIV integration and strategies for drug development. You can find our previous content on HIV and immunity over at cvrblog.myportfolio.com , email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Featuring: Greg Towers, Jack Hirst and Douglas Stewart Editing: Douglas Stewart Music: Inspire - Benjamin Tissot - www.bensound.com

19 MINMAR 4
Comments
How HIV Survives The Minefield - Prof Greg Towers

Getting a really, really close look at viruses

Season 2 Episode 4: It’s hard to get anywhere in microbiology without a microscope, and the cutting edge right now is cryo-electron microscopy, where samples are frozen in clear ice, so they stay in their natural state when they’re viewed. In this week’s episode, Connor is joined by Dr Liz Wright from the University of Wisconsin–Madison, who explains how technological advances have empowered researchers to unpick the structures of viruses like RSV, influenza, and HIV. You can find our previous content on viruses like 'flu and RSV and techniques such as cryoEM - over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Featuring: Connor Bamford and Elizabeth Wright Editing: Jack Hirst Music: Inspire - Benjamin Tissot - www.bensound.com

19 MINFEB 25
Comments
Getting a really, really close look at viruses

Do patient genomes hold the key to fighting viral sepsis?

Season 2 Episode 3: This week we're discussing sepsis, a major complication of infection (from bacteria AND viruses) which can lead to multiple organ failure and death. Following on from the first two episodes in this series, influenza virus in one such infection that can lead to sepsis. The only treatments for sepsis are indirect drugs that target the cause of infection – fine when good drugs are available, but this isn’t the case for all pathogens. In this episode Connor and Jack are joined by Dr Kenny Baillie from the University of Edinburgh, who explains how it could be patients’ own DNA which holds the key to targeting sepsis directly. You can find our previous content on influenza over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Featuring: Connor Bamford, Jack Hirst, and Kenny Baillie Editing: Jack Hirst Music: Inspire - Benjamin Tissot - www.bensound.com

22 MINFEB 18
Comments
Do patient genomes hold the key to fighting viral sepsis?

The physics of influenza virus replication with Dr Nicole Robb

Season 2 Episode 2: Today we are discussing another virus everyone is familiar with, especially now the winter season is here, influenza. But today we are changing tack, and bringing some physics into the mix. Joining us (postdocs Shirin Ashraf and Connor Bamford) is Dr. Nicole Robb, from the University of Oxford. Dr. Robb is a virologist, who likes to approach viruses at the single molecule level, armed with tools from the physical world. Let's hear her exciting journey through interdisciplinary sciences and the potential of using physics to solve biological questions. You can listen to all our podcasts at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Join us next week when we talk to Dr. Ken Baillie on some more exciting approaches to influenza! Until then, goodbye from contagious thinking! You can find our previous content on influenza over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Fe...

19 MINFEB 11
Comments
The physics of influenza virus replication with Dr Nicole Robb

Yoshihiro Kawaoka - 2018 Sir Michael Stoker Prize Podcast

Season 2 Episode 1: Today we’re welcoming a very special guest to Contagious Thinking, Prof Yoshihiro Kawaoka, the 2018 Sir Michael Stoker Prize winner. The Stoker prize is an annual lecture awarded to an influential virologist, chosen by everyone who is not a group leader or PI at the CVR. Previous winners include David Baltimore, Beatrice Hahn and Jon Yewdell, to name only a few. This year’s winner, Yoshi Kawaoka - who is a vet by training - works at both the University of Wisconsin - Madison and the University of Tokyo. In this episode, Kawaoka speaks with fellow postdocs Elihu Aranday-Cortes, Shirin Ashraf and Connor Bamford, about his life in science; his interests in dangerous viruses like Ebola virus and Influenza viruses; and what its like to balance working life in Japan and in the USA. You can find our previous content on influenza and Ebola - and other Stoker prize winner lectures - over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us...

43 MINFEB 4
Comments
Yoshihiro Kawaoka - 2018 Sir Michael Stoker Prize Podcast

David Baltimore - Winner of the 2017 Sir Michael Stoker Award (Series 1 Episode 8)

In the last episode of our current series Jack, Yasmin and Andrew are joined by renowned virologist and Nobel laureate Professor David Baltimore, the 2017 winner of the CVR's Sir Michael Stoker Award, to discuss his career. David and his lab have been involved in key developments in virology such as discovering reverse transcriptase (and therefore retroviruses) and making the first infectious clone of an RNA virus. If you like this podcast check out some of our previous content about viruses including HIV over at cvrblogs.myportfolio.com. Music: The Zeppelin by Blue Dot Sessions (freemusicarchive.org/music/Blue_Dot…_Zeppelin_1908)

21 MIN2018 JUL 26
Comments
David Baltimore - Winner of the 2017 Sir Michael Stoker Award (Series 1 Episode 8)

Fighting viruses across Africa with Ian Goodfellow (Series 1 Episode 7)

This week Connor, Jack and Andrew are joined by Professor Ian Goodfellow from the University of Cambridge to hear about his career so far in virology and his recent work in helping stop viruses in Africa including during the recent West African Ebola outbreak. If you like this podcast check out some of our previous content about viruses like ebola virus over at cvrblogs.myportfolio.com. Music: The Zeppelin by Blue Dot Sessions (freemusicarchive.org/music/Blue_Dot…_Zeppelin_1908)

19 MIN2018 JUL 18
Comments
Fighting viruses across Africa with Ian Goodfellow (Series 1 Episode 7)

Latest Episodes

Robert J. Gifford: Sequence, Blast, rinse and repeat

In this final episode, we change gears, from innate immunity to virus biology and evolution. Today, postdocs Connor and Elihu talk with Dr. Robert Gifford, CVR’s resident evolutionary virologist and senior research fellow. Rob’s lab combines sequence data and software development to explore virus genomics and coevolution of viruses and their hosts. He applies virus genomics to help and guide treatment of HCV-infected patients; support genomic surveillance and outbreak response for bluetongue and rabies; and explore the diversity of endogenous viral elements in published genome sequence data, just to name a few of his projects. Listen to him tell us how he became interested in this paleovirology by starting out working on endogenous retroviruses at Imperial College long before the NGS metagenomics techniques come about. Thank you for listening to us, and thanks to Rob for joining us this episode. As always, you can find our previous content at https://cvrblog.myportfolio.com/, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog Join us next season with more new hosts and more contagious thinking. Featuring: Connor Bamford, Elihu Aranday-Cortes and Robert J. Gifford Editing: Elihu Aranday-Cortes Music: Inspire - Benjamin Tissot - www.bensound.com

62 MINMAR 26
Comments
Robert J. Gifford: Sequence, Blast, rinse and repeat

Marlene Dreux and the interferogenic synapse

Season 2 Episode 7: Today Connor's following on the theme of innate immunity started by Greg and Adam in the last two episodes and is joined by Dr Marlene Dreux, Team Leader in immunovirology at the Centre International de Recherche en Infectiologie (CIRI) in Lyon, France. Marlene combines cell biology, viruses and immunity to find out how our cells sense viral infections, like dengue, chikungunya and hepatitis C virus, to keep us safe. The Dreux lab very recently published a study identifying a new cell communication structure, the 'interferogenic synapse' that acts to block viral infection. See the pre-print here: https://www.biorxiv.org/content/10.1101/374496v1 Listen to her tell us how she became interested in this anti-arbovirus immunity by starting out working on HCV in France and then in the USA. You can find our previous content on antivirus immunity over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Join us next week when we're sticking looking at one of the CVR's own researchers, resident evolutionary virologist Dr Rob Gifford. Featuring: Connor Bamford & Marlene Dreux Editing: Connor Bamford Music: Inspire - Benjamin Tissot - www.bensound.com

15 MINMAR 18
Comments
Marlene Dreux and the interferogenic synapse

Biochemistry of innate immunity with Adam Fletcher

Season 2 Episode: 6 I hope you enjoyed last week’s episode with Jack, Douglas and Greg Towers because now we’re continuing on that theme and speaking with Dr Adam Fletcher, a fellow innate/intrinsic immunity enthusiast, like Greg. Adam (https://scholar.google.co.uk/citations?user=cEzmpPEAAAAJ&hl=en), has led work on fantastic papers onto the detailed molecular mechanisms that our cells use to seek, destroy and ultimate block disease-causing viruses, like HIV, from infecting us. One example if the very recent paper in Cell Host & Microbe https://www.sciencedirect.com/science/article/pii/S1931312818305456 (from which our cover image is from). Adam worked previously with Leo James at the Laboratory of Molecular Biology or LMB in Cambridge, and actually with Greg Towers at University College London. Adam is currently a postdoc working 'around the corner' from us here at in the CVR at the University of Dundee, MRC PPU. In this episode, Adam tells us about his work on antiviral immunity and what it is like being an early-career researcher in virology. As always, you can find our previous content on antiviral immunity over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog Join us next week, where we’ll be joined by Dr Marlene Dreux, who tell us some more about the antiviral immune response through the lens of cell biology. Featuring: Elihu Aranday-Cortes, Connor Bamford and Adam Fletcher. Editing: Connor Bamford Music: Inspire - Benjamin Tissot - www.bensound.com

17 MINMAR 11
Comments
Biochemistry of innate immunity with Adam Fletcher

How HIV Survives The Minefield - Prof Greg Towers

Season 2 Episode 5: Having heard about Dr Liz Wright's work with HIV and Cryo EM last week, this week Jack and Douglas take a deep dive into the HIV field with Professor Greg Towers. Having established a enduring interest in HIV virology at a young age, Prof. Towers and his lab - based at University College London - work on some of the fundamental questions of HIV virology, including trying to understand what the differences are between pandemic strains and non-pandemic strains of the virus. We chat with Greg about this work and about other aspects of HIV virology, including intrinsic immunity and HIV restriction, HIV integration and strategies for drug development. You can find our previous content on HIV and immunity over at cvrblog.myportfolio.com , email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Featuring: Greg Towers, Jack Hirst and Douglas Stewart Editing: Douglas Stewart Music: Inspire - Benjamin Tissot - www.bensound.com

19 MINMAR 4
Comments
How HIV Survives The Minefield - Prof Greg Towers

Getting a really, really close look at viruses

Season 2 Episode 4: It’s hard to get anywhere in microbiology without a microscope, and the cutting edge right now is cryo-electron microscopy, where samples are frozen in clear ice, so they stay in their natural state when they’re viewed. In this week’s episode, Connor is joined by Dr Liz Wright from the University of Wisconsin–Madison, who explains how technological advances have empowered researchers to unpick the structures of viruses like RSV, influenza, and HIV. You can find our previous content on viruses like 'flu and RSV and techniques such as cryoEM - over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Featuring: Connor Bamford and Elizabeth Wright Editing: Jack Hirst Music: Inspire - Benjamin Tissot - www.bensound.com

19 MINFEB 25
Comments
Getting a really, really close look at viruses

Do patient genomes hold the key to fighting viral sepsis?

Season 2 Episode 3: This week we're discussing sepsis, a major complication of infection (from bacteria AND viruses) which can lead to multiple organ failure and death. Following on from the first two episodes in this series, influenza virus in one such infection that can lead to sepsis. The only treatments for sepsis are indirect drugs that target the cause of infection – fine when good drugs are available, but this isn’t the case for all pathogens. In this episode Connor and Jack are joined by Dr Kenny Baillie from the University of Edinburgh, who explains how it could be patients’ own DNA which holds the key to targeting sepsis directly. You can find our previous content on influenza over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Featuring: Connor Bamford, Jack Hirst, and Kenny Baillie Editing: Jack Hirst Music: Inspire - Benjamin Tissot - www.bensound.com

22 MINFEB 18
Comments
Do patient genomes hold the key to fighting viral sepsis?

The physics of influenza virus replication with Dr Nicole Robb

Season 2 Episode 2: Today we are discussing another virus everyone is familiar with, especially now the winter season is here, influenza. But today we are changing tack, and bringing some physics into the mix. Joining us (postdocs Shirin Ashraf and Connor Bamford) is Dr. Nicole Robb, from the University of Oxford. Dr. Robb is a virologist, who likes to approach viruses at the single molecule level, armed with tools from the physical world. Let's hear her exciting journey through interdisciplinary sciences and the potential of using physics to solve biological questions. You can listen to all our podcasts at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Join us next week when we talk to Dr. Ken Baillie on some more exciting approaches to influenza! Until then, goodbye from contagious thinking! You can find our previous content on influenza over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us @CVRblog. Fe...

19 MINFEB 11
Comments
The physics of influenza virus replication with Dr Nicole Robb

Yoshihiro Kawaoka - 2018 Sir Michael Stoker Prize Podcast

Season 2 Episode 1: Today we’re welcoming a very special guest to Contagious Thinking, Prof Yoshihiro Kawaoka, the 2018 Sir Michael Stoker Prize winner. The Stoker prize is an annual lecture awarded to an influential virologist, chosen by everyone who is not a group leader or PI at the CVR. Previous winners include David Baltimore, Beatrice Hahn and Jon Yewdell, to name only a few. This year’s winner, Yoshi Kawaoka - who is a vet by training - works at both the University of Wisconsin - Madison and the University of Tokyo. In this episode, Kawaoka speaks with fellow postdocs Elihu Aranday-Cortes, Shirin Ashraf and Connor Bamford, about his life in science; his interests in dangerous viruses like Ebola virus and Influenza viruses; and what its like to balance working life in Japan and in the USA. You can find our previous content on influenza and Ebola - and other Stoker prize winner lectures - over at cvrblog.myportfolio.com, email us at cvrcontagiousthinking@gmail.com or tweet us...

43 MINFEB 4
Comments
Yoshihiro Kawaoka - 2018 Sir Michael Stoker Prize Podcast

David Baltimore - Winner of the 2017 Sir Michael Stoker Award (Series 1 Episode 8)

In the last episode of our current series Jack, Yasmin and Andrew are joined by renowned virologist and Nobel laureate Professor David Baltimore, the 2017 winner of the CVR's Sir Michael Stoker Award, to discuss his career. David and his lab have been involved in key developments in virology such as discovering reverse transcriptase (and therefore retroviruses) and making the first infectious clone of an RNA virus. If you like this podcast check out some of our previous content about viruses including HIV over at cvrblogs.myportfolio.com. Music: The Zeppelin by Blue Dot Sessions (freemusicarchive.org/music/Blue_Dot…_Zeppelin_1908)

21 MIN2018 JUL 26
Comments
David Baltimore - Winner of the 2017 Sir Michael Stoker Award (Series 1 Episode 8)

Fighting viruses across Africa with Ian Goodfellow (Series 1 Episode 7)

This week Connor, Jack and Andrew are joined by Professor Ian Goodfellow from the University of Cambridge to hear about his career so far in virology and his recent work in helping stop viruses in Africa including during the recent West African Ebola outbreak. If you like this podcast check out some of our previous content about viruses like ebola virus over at cvrblogs.myportfolio.com. Music: The Zeppelin by Blue Dot Sessions (freemusicarchive.org/music/Blue_Dot…_Zeppelin_1908)

19 MIN2018 JUL 18
Comments
Fighting viruses across Africa with Ian Goodfellow (Series 1 Episode 7)