The most interesting people in the world of science and technologySTEM-Talk is an interview podcast show produced by the Florida Institute for Human and Machine Cognition, a not-for-profit research lab pioneering ground-breaking technologies aimed at leveraging and extending human cognition, perception, locomotion and resilience. Twice a month, we talk to groundbreaking scientists, engineers and technologists. Our interviews focus on the science that our subjects are engaged with, as well as their careers, motivations, education, and passions. Think of them as “profiles in science.” Tune in every other Tuesday to our show—and if you like us, please write a review of STEM-talk—and spread the word.
Episode 81: Charles Brenner discusses NR and the benefits of boosting NAD as we age
Our guest today is Dr. Charles Brenner, the Roy J. Carver Chair of Biochemistry at the University of Iowa. Charles is one of the world’s leading experts on nicotinamide adenine dinucleotide, commonly referred to as NAD, which is an essential molecule found in every living cell. In 2004, he discovered the nicotinamide riboside kinase pathway, which leads to a special form of vitamin B3. We talk to Charles about his research into NAD and why he believes supplementation with NR could help people age better. In addition to his work at the University of Iowa, he is also the chief scientific advisor for ChromaDex,which markets the NR supplement Tru Niagen. In today’s interview, we cover: [00:06:29] How Charles became the first cancer biology graduate student in the biology department at Stanford University. [00:07:51] Charles’ research into nicotinamide adenine dinucleotide (NAD) during his time on the faculty at Thomas Jefferson University. [00:09:15] Charles’ discovery that nicotinamide riboside (NR) is a precursor of NAD. [00:19:47] Why Charles doesn’t use the term “anti-aging.” [00:25:52] The importance of nicotinamide adenine dinucleotide phosphate (NADPH) and its role as the central regulator of reactive oxygen species toxicity. [00:34:56] The circadian rhythms of NAD and the potential benefit of diurnal dosing. [00:38:45] Why skeletal muscle is one of the most sensitive target tissues for the anti-aging effects of NMN. [00:45:42] How the benefits of a ketogenic diet, intermittent fasting, time restricted eating could be related to NAD. [00:47:02] A recent human trial conducted by the University of Coloradothat found Niagen increased NAD+ by 60 percent in healthy middle-aged and older adults after just six weeks. [00:49:19] The optimal dose of NR for humans.
Episode 80: Butler Hine talks about paving the way for robotic space exploration
Our guest today is Dr. Butler Hine, the Flight Project Manager and Chief Technologist for Engineering at the NASA Ames Research Center in Mountain View, California. Butler is also a senior research scientist and a colleague of Ken and Dawn at IHMC. Butler is currently the project manager for NASA’s Arcus mission, which is an X-ray observatory that has a possible launch date of 2023. The mission will include a high-resolution X-ray grating spectrometer that will study the hot gas that is the dominant component of the normal matter in the Universe, much of which has not yet been directly seen. In today’s interview, we discuss: [00:03:57] How Butler became interested in astronomy and started building telescopes as a youth. [00:08:37] How Butler wound up managing the robotics lab at NASA. [00:11:55] The challenges of trying to change the thinking of the science community about ways to adapt technology to science. [00:17:34] Artificial intelligence and data mining. [00:26:59] The Lunar...
Episode 79: Satchin Panda discusses circadian rhythms and time-restricted eating to improve health and even reverse disease
Dr. Satchin Panda is a professor and researcher at the Salk Institutewho has become recognized as one of the world’s leading experts on circadian rhythm. In today’s wide-ranging interview, he discusses how the body’s natural day-night cycle can help us improve our health, get a better night’s sleep and lose weight. He also shares how adopting a lifestyle that is aligned with the body’s natural internal clock can even help us prevent and reverse disease. Satchin also has been generating significant attention for his research into the health benefits of time-restricted eating. He is the author of “The Circadian Code”and in today’s interview he shares how listeners can become involved in a research project he and his colleagues are conducting through a smartphone app called My Circadian Clock. In addition to his work at the Salk Institute, Satchin is also a founding executive member of the Center for Circadian Biology at the University of California, San Diego. Key topics cover...
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