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Science on Saturday (Audio)

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Science on Saturday (Audio)

Science on Saturday (Audio)

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Join a group of science teachers and middle and high school students on a field trip to Lawrence Livermore National Laboratory (LLNL) for the annual Science on Saturday (SOS) lecture series. Presented by leading LLNL researchers and supported by master high school science teachers, each topic highlights cutting-edge science occurring at the lab.

Latest Episodes

Crossing the Blood Brain Barrier: One Byte at a Time

The blood-brain-barrier (BBB) is a special structure in the body that helps to protect the brain from unwanted toxins and germs. Unfortunately, this barrier can also make it extremely difficult for therapeutics to reach their intended target within brain. Lawrence Livermore Lab scientists describe how combining experimental techniques with computational methods, making use of some of the fastest supercomputers in the world, can speed up the process of optimizing therapeutics to cross the BBB. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34467]

53 MINJAN 6
Comments
Crossing the Blood Brain Barrier: One Byte at a Time

3D Bioprinted Model for Metastatic Brain Tumors

Cancer becomes highly dangerous when it spreads from its original site to a different vital organ. These secondary tumors called metastases are what kill most patients. Despite hundreds of years of research, it is not understood why, where, and how cancer spreads to organs like the brain. Lawrence Livermore Lab scientist describes how they bring together cancer biology, 3D printing and material science, to understand and hopefully prevent metastases in the future. Series: "Lawrence Livermore National Lab Science on Saturday" [Health and Medicine] [Science] [Show ID: 34466]

46 MIN2019 JUL 17
Comments
3D Bioprinted Model for Metastatic Brain Tumors

In the Mood: Deciphering Complex Brain Signals

The human brain contains approximately 86 billion neurons, and 100 trillion connections between those neurons. Despite our inability to image each neuron and determine their exact connective patterns, several approaches for noninvasive imaging of the living brain have been developed and utilized to great benefit. LLNL scientist Alan Kaplan explores the immense landscape of the human brain and quantifies the brain in terms of data flow. Then describes engineering applications of recorded electrophysiological data and explores methods for analyzing such data to determine the pattern of signals that arise during various activities and mood states. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34465]

45 MIN2019 JUN 23
Comments
In the Mood: Deciphering Complex Brain Signals

Giving Your Brain a Voice: Engineering Sensors That Listen to Brain Cells

The human brain is composed of billions of cells that communicate through chemical and electrical signals. LLNL microelectrodes can interface directly with the brain to allow us to monitor and manipulate the dynamics of these brain signals. LLNL microelectrodes are flexible and microfabricated in dense arrays that allow them to collect large amounts of information over long periods of time in the body. Scientists Anna Belle and Allison Yorita go over how these arrays are microfabricated and their diagnostic and therapeutic applications. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34464]

46 MIN2019 JUN 19
Comments
Giving Your Brain a Voice: Engineering Sensors That Listen to Brain Cells

Biomolecular Action Movies: Flash Imaging with X-ray Lasers

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

53 MIN2018 JUN 28
Comments
Biomolecular Action Movies: Flash Imaging with X-ray Lasers

Improving Human Health One Atom at a Time - Biomedical Accelerator Mass Spectrometry

Accelerator mass spectrometry (AMS) is a sensitive mass spectrometric method for detecting and quantifying rare long-lived isotopes with high precision. This technique is widely employed in the earth and environmental sciences and is now being applied in the biomedical fields. AMS is primarily used to in the areas of pharmacology and toxicology to investigate the absorption, distribution, metabolism, and excretion of radiolabeled drugs, chemicals, and nutrients, as well as in the detection of chemically modified DNA and proteins in animal models and humans. The exquisite sensitivity (10-18 mol) of AMS allows for the use of low chemical and radioisotope doses and relatively small sample sizes, which enables studies to be performed safely in humans, using exposures that are environmentally or therapeutically relevant. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33431]

43 MIN2018 JUN 18
Comments
Improving Human Health One Atom at a Time - Biomedical Accelerator Mass Spectrometry

The Evolution of Computing Technologies: From Following Instructions to Learning

How often do you wonder about supercomputers and computers that "think" like humans? Supercomputers have been used to model complex scientific phenomena for decades. Now, scientists are entering a new era in computing, and computers are learning in a way that is similar to the human brain. With enough information, computers can learn to solve problems in novel and interesting ways. Specialized computers can even solve these problems using significantly less energy than "classical" computers. This talk describes using supercomputers to solve challenging problems and the evolving technologies of learning systems. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33430]

37 MIN2018 JUN 14
Comments
The Evolution of Computing Technologies: From Following Instructions to Learning

Laser-Plasma Accelerators: Riding the Wave to the Next Generation X-Ray Light Sources

Particle accelerators have been revolutionizing discoveries in science, medicine, industry and national security for over a century. An estimated 30,000 particle accelerators are currently active around the world. In these machines, electromagnetic fields accelerate charged particles, such as electrons, protons, ions or positrons to velocities nearing the speed of light. Although their scientific appeal will remain evident for many decades, one limitation of the current generation of particle accelerators is their tremendous size, typically a mile long, and cost, which often limits access to the broader scientific community. Acceleration of electrons in plasmas, in particular in laser-driven plasmas, has been drawing considerable attention over the past decade. These laser wakefield accelerators promise to dramatically reduces the size of accelerators and revolutionize applications in medicine, industry, and basic sciences. Series: "Lawrence Livermore National Lab Science on Saturda...

48 MIN2018 JUN 7
Comments
Laser-Plasma Accelerators: Riding the Wave to the Next Generation X-Ray Light Sources

Building Biologically Inspired Nano-Bots

Find out about both synthetic and molecular biology approaches to produce small nano-machines (nano-bots). The main building blocks for these nano-bots are based on nano-lipo-protein particles (NLPs). Nano-bots represent a unique solution for new approaches to vaccines, drug delivery and energy needs. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 32074]

47 MIN2017 JUL 3
Comments
Building Biologically Inspired Nano-Bots

3D Printing: From Imagination to Realization

Revolutionary changes to materials and structures are now possible with 3D printing, bringing concepts that were previously only imagined into reality. This breakthrough technology fabricates components by adding material layer by layer from the bottom up allowing for the creation of highly complex and previously unrealizable structures. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 32073]

51 MIN2017 MAY 15
Comments
3D Printing: From Imagination to Realization

Latest Episodes

Crossing the Blood Brain Barrier: One Byte at a Time

The blood-brain-barrier (BBB) is a special structure in the body that helps to protect the brain from unwanted toxins and germs. Unfortunately, this barrier can also make it extremely difficult for therapeutics to reach their intended target within brain. Lawrence Livermore Lab scientists describe how combining experimental techniques with computational methods, making use of some of the fastest supercomputers in the world, can speed up the process of optimizing therapeutics to cross the BBB. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34467]

53 MINJAN 6
Comments
Crossing the Blood Brain Barrier: One Byte at a Time

3D Bioprinted Model for Metastatic Brain Tumors

Cancer becomes highly dangerous when it spreads from its original site to a different vital organ. These secondary tumors called metastases are what kill most patients. Despite hundreds of years of research, it is not understood why, where, and how cancer spreads to organs like the brain. Lawrence Livermore Lab scientist describes how they bring together cancer biology, 3D printing and material science, to understand and hopefully prevent metastases in the future. Series: "Lawrence Livermore National Lab Science on Saturday" [Health and Medicine] [Science] [Show ID: 34466]

46 MIN2019 JUL 17
Comments
3D Bioprinted Model for Metastatic Brain Tumors

In the Mood: Deciphering Complex Brain Signals

The human brain contains approximately 86 billion neurons, and 100 trillion connections between those neurons. Despite our inability to image each neuron and determine their exact connective patterns, several approaches for noninvasive imaging of the living brain have been developed and utilized to great benefit. LLNL scientist Alan Kaplan explores the immense landscape of the human brain and quantifies the brain in terms of data flow. Then describes engineering applications of recorded electrophysiological data and explores methods for analyzing such data to determine the pattern of signals that arise during various activities and mood states. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34465]

45 MIN2019 JUN 23
Comments
In the Mood: Deciphering Complex Brain Signals

Giving Your Brain a Voice: Engineering Sensors That Listen to Brain Cells

The human brain is composed of billions of cells that communicate through chemical and electrical signals. LLNL microelectrodes can interface directly with the brain to allow us to monitor and manipulate the dynamics of these brain signals. LLNL microelectrodes are flexible and microfabricated in dense arrays that allow them to collect large amounts of information over long periods of time in the body. Scientists Anna Belle and Allison Yorita go over how these arrays are microfabricated and their diagnostic and therapeutic applications. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34464]

46 MIN2019 JUN 19
Comments
Giving Your Brain a Voice: Engineering Sensors That Listen to Brain Cells

Biomolecular Action Movies: Flash Imaging with X-ray Lasers

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

53 MIN2018 JUN 28
Comments
Biomolecular Action Movies: Flash Imaging with X-ray Lasers

Improving Human Health One Atom at a Time - Biomedical Accelerator Mass Spectrometry

Accelerator mass spectrometry (AMS) is a sensitive mass spectrometric method for detecting and quantifying rare long-lived isotopes with high precision. This technique is widely employed in the earth and environmental sciences and is now being applied in the biomedical fields. AMS is primarily used to in the areas of pharmacology and toxicology to investigate the absorption, distribution, metabolism, and excretion of radiolabeled drugs, chemicals, and nutrients, as well as in the detection of chemically modified DNA and proteins in animal models and humans. The exquisite sensitivity (10-18 mol) of AMS allows for the use of low chemical and radioisotope doses and relatively small sample sizes, which enables studies to be performed safely in humans, using exposures that are environmentally or therapeutically relevant. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33431]

43 MIN2018 JUN 18
Comments
Improving Human Health One Atom at a Time - Biomedical Accelerator Mass Spectrometry

The Evolution of Computing Technologies: From Following Instructions to Learning

How often do you wonder about supercomputers and computers that "think" like humans? Supercomputers have been used to model complex scientific phenomena for decades. Now, scientists are entering a new era in computing, and computers are learning in a way that is similar to the human brain. With enough information, computers can learn to solve problems in novel and interesting ways. Specialized computers can even solve these problems using significantly less energy than "classical" computers. This talk describes using supercomputers to solve challenging problems and the evolving technologies of learning systems. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33430]

37 MIN2018 JUN 14
Comments
The Evolution of Computing Technologies: From Following Instructions to Learning

Laser-Plasma Accelerators: Riding the Wave to the Next Generation X-Ray Light Sources

Particle accelerators have been revolutionizing discoveries in science, medicine, industry and national security for over a century. An estimated 30,000 particle accelerators are currently active around the world. In these machines, electromagnetic fields accelerate charged particles, such as electrons, protons, ions or positrons to velocities nearing the speed of light. Although their scientific appeal will remain evident for many decades, one limitation of the current generation of particle accelerators is their tremendous size, typically a mile long, and cost, which often limits access to the broader scientific community. Acceleration of electrons in plasmas, in particular in laser-driven plasmas, has been drawing considerable attention over the past decade. These laser wakefield accelerators promise to dramatically reduces the size of accelerators and revolutionize applications in medicine, industry, and basic sciences. Series: "Lawrence Livermore National Lab Science on Saturda...

48 MIN2018 JUN 7
Comments
Laser-Plasma Accelerators: Riding the Wave to the Next Generation X-Ray Light Sources

Building Biologically Inspired Nano-Bots

Find out about both synthetic and molecular biology approaches to produce small nano-machines (nano-bots). The main building blocks for these nano-bots are based on nano-lipo-protein particles (NLPs). Nano-bots represent a unique solution for new approaches to vaccines, drug delivery and energy needs. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 32074]

47 MIN2017 JUL 3
Comments
Building Biologically Inspired Nano-Bots

3D Printing: From Imagination to Realization

Revolutionary changes to materials and structures are now possible with 3D printing, bringing concepts that were previously only imagined into reality. This breakthrough technology fabricates components by adding material layer by layer from the bottom up allowing for the creation of highly complex and previously unrealizable structures. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 32073]

51 MIN2017 MAY 15
Comments
3D Printing: From Imagination to Realization
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