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The COVID-19 LST Report

COVID19LST

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The COVID-19 LST Report

The COVID-19 LST Report

COVID19LST

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The COVID-19 Literature Surveillance Team is a group of physicians, medical students, PhDs and others that are keeping up with the latest research on SARS-CoV-2. We find the newest articles, read them and grade their level of evidence to bring you the bottom line.Visit COVID19LST.org for full daily report with links to articles.Contact us at: contact@covid19lst.orgProducer: Stephen FerraroMedia: Kealapono RichardsonWriters: Thamanna Nishath and Brennan EnrightHost: Jasmine Rah © 2020 | COVID19LST.org

Latest Episodes

June 29, 2020

On today's episode we discuss: —Climate: A cross-sectional study of 640 adults found that COVID-19-related conspiracy theory (CT) beliefs correlated with pre-existing CT beliefs, lower education levels, and a negative perception of government responses. However, there was no correlation between CT beliefs and emotional stress during the pandemic. —Epidemiology: A multicenter retrospective cohort study from Wuhan comparing pediatric and adult COVID-19 patients found children were more likely to be asymptomatic, have lymphocytosis (vs lymphopenia in adults) and were less likely to respond to anti-viral treatments. —Management: A prospective clinical study from the University of Utah suggest that SARS-CoV-2 infection induces activating changes in the transcriptome and proteome of platelets, possibly contributing to the immunothrombosis observed in COVID-19 disease. —Diagnosis and Treatment: Canadian authors describe policies implemented to reduce spread of infection in a 182-bed psychiatric facility, concluding that rapid identification of cases, aggressive testing for carriers, and swift movement of patients to isolation units are necessary to reduce nosocomial spread of COVID-19. — Management: Spanish authors describe pulmonary parameters in COVID-19 patients with acute respiratory distress syndrome (ARDS), finding a lack of association between PaO2/FiO2 and static compliance of the respiratory system, and a significant increase in oxygenation with prone position. They propose the underlying hypoxemia in COVID-19 ARDS results from dysfunction in lung perfusion. — Adjusting Practice: The authors argue that the emergency department is an unideal setting for making medical decisions regarding geriatric patients during the COVID-19 pandemic due to the paucity of critical information and the necessity for quick decisions. The authors suggest implementing diverse triage teams with administrative leadership, informing providers with regards to advanced directives, and delaying intubation until better decision-making can be made to improve patient outcomes and promote patient autonomy and beneficence. —R&D Diagnosis and Treatment: A meta-analysis of chest CT features in 2,451 COVID-19 pneumonia patients found that vascular enlargement, ground glass opacities, interlobar septal thickening, and subpleural bands are the most common findings. -An in vivo drug trial of Remdesivir in a rhesus macaque animal model found reduced pulmonary findings on chest radiographs, reduced viral titers on bronchoalveolar lavage (BAL), and reduced lung damage on pathology, suggesting early initiation of Remdesivir may provide clinical benefit in severe COVID-19 respiratory disease.

7 MIN1 w ago
Comments
June 29, 2020

June 26, 2020

On today's episode we discuss: —Climate: A survey of 426 emergency physicians from seven medical institutions in California, New Jersey, and Louisiana found inadequacy of PPE, inability to quickly and accurately diagnose COVID-19, and fear of infecting family members to be the most salient stressors. —Epidemiology: A systematic review and meta-analysis, including 148 articles comprised of 24,410 COVID-19 positive adults from 9 countries, found that the most common symptoms at presentation were fever (78%), cough (57%), and fatigue (31%), with prevalence of dyspnea in only 23% of patients. The authors conclude that the most common symptoms are fever and cough, although it is noted that these prevalence findings are about 10% less than previously reported. —Management: A case series of 7 patients found that postmortem tissue samples from patients who died from COVID-19 pneumonia <7 days after onset of respiratory failure (RF) showed acute diffuse alveolar damage (DAD) while samples from those who died >14 days after onset of RF showed organizing DAD, with SARS-CoV-2 detected in tissues with acute DAD but not in tissues with organizing DAD. —Diagnosis and Treatment: - Analysis of three case series with conflicting data on mechanically ventilated COVID-19 patients indicated that: 1) low respiratory system compliance (Crs) may be associated with a higher gradient of arterial partial pressures of oxygen to alveolar partial pressures of oxygen (PaO2-PAO2) in COVID-19 respiratory failure, 2) positive end-expiratory pressure (PEEP) levels should be selected by measuring Crs, and 3) increasing tidal volume can reduce both serial dead space ventilation and parallel dead space ventilation. The authors suggest that clinicians focus on individual patient's needs when operating respirators given the heterogeneity in presentations of COVID-19 respiratory failure. - A cross-sectional study conducted by Tulane University School of Medicine using 29 nasal swab samples and found that COVID-19 could be diagnosed within 50 minutes via a COVID-19 CRISPR fluorescent detection system (FDS) with 100% sensitivity and 71.4% specificity when compared to results obtained by a state testing laboratory via reverse transcriptase (RT)-PCR of the same samples —Mental Health and Resilience: - Authors of the Department of Addictive Behavior and Addictive Medicine in Mannheim, Germany evaluated the effect of social isolation on alcohol consumption during the pandemic through an anonymous online survey of 2,102 participants and found that 34.7% of participants reported drinking more alcohol since the lockdown began, highlighting the need for healthcare providers to stay informed on this increased alcohol consumption during the lockdown and to be aware of its potential long-term effects. - A systematic review conducted at the Galatea Care Programme for Sick Health Professionals in Barcelona, Spain analyzed 30 studies and found a high prevalence of anxiety (30-70%) and depressive symptoms (20-40%) reported among healthcare professionals (HPs), raising concerns that increased psychological support is needed in these population.

7 MIN2 w ago
Comments
June 26, 2020

June 25, 2020

On today's episode we discuss: —Climate: A survey of 2,402 adults in the United States found that 79.5% of respondents supported government-issued stay-at-home orders and nonessential business closures and 77.3% reported they were self-isolating at home suggesting that attitudes broadly support COVID-19 public health interventions. —Epidemiology: A study of data on 1353 COVID-19 positive children found the three most common symptoms in these children were fever (21.7%), cough (15.4%), and abnormal breathing (8.1%) with the most severe manifestations, such as intubation or myocarditis, occurring in less than 0.7% of patients, and 1.9% of patients required ICU care. —Transmission and Prevention: A report by the Center for Disease Control and Prevention of the COVID-19 outbreak that ocurred on the USS Theodore Roosevelt showed that 60% of respondents exhibited evidence of exposure to SARS-CoV-2 via positive neutralizing antibody assay, ageusia and anosmia were the symptoms most associated with current or previous infection among crew members, and 212 (90.2%) of the 235 respondents that reported a previous positive COVID-19 test via RT-PCR tested positive for neutralizing antibodies. —Management: Guidelines for managing COVID-19 patients includes: Diagnosis, treatment, and prevention of venous thromboembolic disease and Donor and candidate selection for transplants. —Diagnosis and Treatment: - A retrospective study found that patients with diminished ovarian reserve who delayed in vitro fertilization treatment (to 90 -180 days from their first visit) had similar live birth rates transfer than those that did not suggesting that delaying IVF in these patients does not affect live birth rate. This data can facilitate decision-making concerning treatment delays and disruptions in this population during the COVID-19 pandemic. - A meta-analysis of 22 studies assessing the diagnostic efficiency of anti-SARS-CoV-2 IgG and IgM tests found specificities of 99% in both tests and sentisivities of 85% and 74% for IgG and IgM respectively. - Analysis of SARS-CoV-2 IgM and total antibody levels in 192 patients with severe or mild COVID-19 found no statistically significant differences between mild and severe COVID-19 cases within 6 days of disease onset; however, after day 6, severe cases exhibited higher IgM and a higher overall positivity rate for total antibody titers than that of mild cases. Further, 12/35 mild cases never exhibited IgM positivity and 5/35 remained negative for total antibody titers highlighting the possible limitations in antibody testing of patients with mild COVID-19

5 MIN2 w ago
Comments
June 25, 2020

June 23, 2020

On today's episode we discuss: —Climate: A study conducted by the Center for Disease Control and Prevention of 2,402 Americans in May found widespread support of the implementation of public health orders such as stay-at-home orders, use of face coverings, and business closures, in response to the COVID-19 pandemic. —Epidemiology: A cross-sectional study in Indianapolis found that 3.1% of 2,953 asymptomatic adults tested positive for SARS-CoV-2 by nasopharyngeal swab testing. Of the 81 SARS-CoV-2 positive participants who completed a follow-up interview, 71.6% remained asymptomatic at 14 days while the other 28.4% reported one or more symptoms. —Management: A group of researchers in Toronto suggest SARS-CoV-2 disruption of the renin angiotensin aldosterone system (RAAS) leads to an endothelial imbalance that leaves the endothelium susceptible to inflammation, vasoconstriction, platelet activation, and thrombosis thus playing a major role in the disease. —Diagnosis and Treatment: A study of 190 patients found that oropharyngeal/nares swabs and nasopharyngeal swabs had sensitivities of 91.7% and 94.4%, respectively, suggesting that oropharyngeal/nares sampling, which may be more readily available during the COVID-19 pandemic, is an effective alternative to nasopharyngeal swabs in ambulatory settings —Mental Health and Resilience: Psychiatrists and addiction medicine experts from Germany conducted a survey of 2,102 German citizens and found that 34.7% of respondents have consumed “more or much more” alcohol during the pandemic compared to their baseline, and indicated that increased alcohol consumption during this time is associated with lower educational status and increased stress.

6 MIN2 w ago
Comments
June 23, 2020

June 22, 2020

On today's episode we discuss: —Climate: An analysis of the economic impact of COVID-19 on older adults highlights that more than 1/3 of adults 65 years or older live in counties with a high cost of living and increased COVID-19 prevalence demonstrating an overlap between "infection rates and economic insecurities" during COVID-19 with nearly 25% of these adults relying on Social Security benefits that may be insufficient to meet financial needs during a pandemic. The authors encourage employment and economic recovery strategies to take into consideration the older population —Epidemiology: A two-center retrospective study at Wuhan Pulmonary Hospital and Tongji Hospital examining 1,018 COVID-19 patients found that increased interleukin-6 (IL-6) levels (>20 pg/mL; P<0.001) and decreased CD8+ T cell levels (<165 cells/mul; P<0.001) are both independently associated with increased mortality in patients with COVID-19, suggesting that both of these indicators may help clinicians in prognostication and clinical decision making. —Management: A case series of 63 positive end-expiratory pressure (PEEP) titrations performed in 15 patients with COVID-19-related ARDS using electrical impedance tomography (EIT) found that high PEEP were from personalized PEEP at the level of lowest relative alveolar overdistention and collapse, PEEP set was positively correlated to BMI (p< 0.001), and individualized PEEP titration could result in improved clinical outcomes but further research is needed to confirm whether this personalized PEEP titration approach is safe and effective. —Diagnosis and Treatment: A retrospective cohort conducted at Daegu Catholic University School of Medicine in Korea found that 31 COVID-19-positive patients treated with lopinavir-ritonavir had significantly shorter times to negative conversion of viral RNA than 34 COVID-19-positive patients treated with hydroxychloroquine (median, 21 days vs. 28 days; Figure 2); however, time until clinical improvement was not found to be different between these groups.

9 MIN2 w ago
Comments
June 22, 2020

June 18, 2020

On today's episode we discuss: — A cross-sectional study conducted in Indianapolis found that 3.1% of 2,953 adults tested positive for SARS-CoV-2 by nasopharyngeal swab testing. Of the 81 SARS-CoV-2 positive participants who completed a follow-up interview, 71.6% remained asymptomatic at 14 days while the other 28.4% reported one or more symptoms. — A study of 1,353 COVID-19 positive children found the three most common symptoms in this population were fever (21.7%), cough (15.4%), and abnormal breathing (8.1%) with the most severe manifestations, such as intubation or myocarditis, occurring in less than 0.7% of patients, and only 1.9% of patients requiring ICU care. — An event-study model utilizing data from 15 states plus Washington, D.C. that had implemented mandatory masks in public revealed a statistically significant decrease in daily county-level growth rates of COVID-19 after implementation of mask wearing mandates, suggesting that transmission rates of COVID-19 may decrease as more states mandate face masks in public. — Pulmonary specialists describe how utilizing nearby hotels for recovering COVID-19 patients discharged from overwhelmed hospitals may be an effective method to meet surging demands citing this approach’s success in certain Italian hospitals. — A review of the mental health impact of the COVID-19 pandemic could increase the risk for suicidal behaviors. — Healthcare reform recommendations are outlined as the current pandemic could be a rare catalyst for major political shifts toward a more efficient and effective system of care, primarily addressing barriers to paying for services and provider reimbursement.

9 MIN2 w ago
Comments
June 18, 2020

June 16, 2020

On today's episode we discuss: — Molecular structures that may contribute to SARS-CoV-2 pathogenicity. — More evidence for SARS in the urine — Dosing medications in COVID-19 patients

9 MIN3 w ago
Comments
June 16, 2020

June 15, 2020

On this episode we discuss - How COVID-19 are causing delays in care seeking with dire consequences - More data regarding surrounding the issue of testing via RTPCR - Factors contributing to moral distress in healthcare workers

9 MINJUN 17
Comments
June 15, 2020

June 13, 2020

On todays report we discuss: – Who is at risk for acute pulmonary embolisms? – What is the state of clinical trials on COVID-19 therapeutics? – Are some patients regain their sense of smell after recovering from their infection?

6 MINJUN 14
Comments
June 13, 2020

June 11, 2020

On todays report, we discuss –How frontline healthcare providers can mitigate sleep deprivation during this pandemic – The connection between obesity and disease severity – Whether or not we should be using CTs with the nasal swab together to diagnose COVID 19

8 MINJUN 13
Comments
June 11, 2020

Latest Episodes

June 29, 2020

On today's episode we discuss: —Climate: A cross-sectional study of 640 adults found that COVID-19-related conspiracy theory (CT) beliefs correlated with pre-existing CT beliefs, lower education levels, and a negative perception of government responses. However, there was no correlation between CT beliefs and emotional stress during the pandemic. —Epidemiology: A multicenter retrospective cohort study from Wuhan comparing pediatric and adult COVID-19 patients found children were more likely to be asymptomatic, have lymphocytosis (vs lymphopenia in adults) and were less likely to respond to anti-viral treatments. —Management: A prospective clinical study from the University of Utah suggest that SARS-CoV-2 infection induces activating changes in the transcriptome and proteome of platelets, possibly contributing to the immunothrombosis observed in COVID-19 disease. —Diagnosis and Treatment: Canadian authors describe policies implemented to reduce spread of infection in a 182-bed psychiatric facility, concluding that rapid identification of cases, aggressive testing for carriers, and swift movement of patients to isolation units are necessary to reduce nosocomial spread of COVID-19. — Management: Spanish authors describe pulmonary parameters in COVID-19 patients with acute respiratory distress syndrome (ARDS), finding a lack of association between PaO2/FiO2 and static compliance of the respiratory system, and a significant increase in oxygenation with prone position. They propose the underlying hypoxemia in COVID-19 ARDS results from dysfunction in lung perfusion. — Adjusting Practice: The authors argue that the emergency department is an unideal setting for making medical decisions regarding geriatric patients during the COVID-19 pandemic due to the paucity of critical information and the necessity for quick decisions. The authors suggest implementing diverse triage teams with administrative leadership, informing providers with regards to advanced directives, and delaying intubation until better decision-making can be made to improve patient outcomes and promote patient autonomy and beneficence. —R&D Diagnosis and Treatment: A meta-analysis of chest CT features in 2,451 COVID-19 pneumonia patients found that vascular enlargement, ground glass opacities, interlobar septal thickening, and subpleural bands are the most common findings. -An in vivo drug trial of Remdesivir in a rhesus macaque animal model found reduced pulmonary findings on chest radiographs, reduced viral titers on bronchoalveolar lavage (BAL), and reduced lung damage on pathology, suggesting early initiation of Remdesivir may provide clinical benefit in severe COVID-19 respiratory disease.

7 MIN1 w ago
Comments
June 29, 2020

June 26, 2020

On today's episode we discuss: —Climate: A survey of 426 emergency physicians from seven medical institutions in California, New Jersey, and Louisiana found inadequacy of PPE, inability to quickly and accurately diagnose COVID-19, and fear of infecting family members to be the most salient stressors. —Epidemiology: A systematic review and meta-analysis, including 148 articles comprised of 24,410 COVID-19 positive adults from 9 countries, found that the most common symptoms at presentation were fever (78%), cough (57%), and fatigue (31%), with prevalence of dyspnea in only 23% of patients. The authors conclude that the most common symptoms are fever and cough, although it is noted that these prevalence findings are about 10% less than previously reported. —Management: A case series of 7 patients found that postmortem tissue samples from patients who died from COVID-19 pneumonia <7 days after onset of respiratory failure (RF) showed acute diffuse alveolar damage (DAD) while samples from those who died >14 days after onset of RF showed organizing DAD, with SARS-CoV-2 detected in tissues with acute DAD but not in tissues with organizing DAD. —Diagnosis and Treatment: - Analysis of three case series with conflicting data on mechanically ventilated COVID-19 patients indicated that: 1) low respiratory system compliance (Crs) may be associated with a higher gradient of arterial partial pressures of oxygen to alveolar partial pressures of oxygen (PaO2-PAO2) in COVID-19 respiratory failure, 2) positive end-expiratory pressure (PEEP) levels should be selected by measuring Crs, and 3) increasing tidal volume can reduce both serial dead space ventilation and parallel dead space ventilation. The authors suggest that clinicians focus on individual patient's needs when operating respirators given the heterogeneity in presentations of COVID-19 respiratory failure. - A cross-sectional study conducted by Tulane University School of Medicine using 29 nasal swab samples and found that COVID-19 could be diagnosed within 50 minutes via a COVID-19 CRISPR fluorescent detection system (FDS) with 100% sensitivity and 71.4% specificity when compared to results obtained by a state testing laboratory via reverse transcriptase (RT)-PCR of the same samples —Mental Health and Resilience: - Authors of the Department of Addictive Behavior and Addictive Medicine in Mannheim, Germany evaluated the effect of social isolation on alcohol consumption during the pandemic through an anonymous online survey of 2,102 participants and found that 34.7% of participants reported drinking more alcohol since the lockdown began, highlighting the need for healthcare providers to stay informed on this increased alcohol consumption during the lockdown and to be aware of its potential long-term effects. - A systematic review conducted at the Galatea Care Programme for Sick Health Professionals in Barcelona, Spain analyzed 30 studies and found a high prevalence of anxiety (30-70%) and depressive symptoms (20-40%) reported among healthcare professionals (HPs), raising concerns that increased psychological support is needed in these population.

7 MIN2 w ago
Comments
June 26, 2020

June 25, 2020

On today's episode we discuss: —Climate: A survey of 2,402 adults in the United States found that 79.5% of respondents supported government-issued stay-at-home orders and nonessential business closures and 77.3% reported they were self-isolating at home suggesting that attitudes broadly support COVID-19 public health interventions. —Epidemiology: A study of data on 1353 COVID-19 positive children found the three most common symptoms in these children were fever (21.7%), cough (15.4%), and abnormal breathing (8.1%) with the most severe manifestations, such as intubation or myocarditis, occurring in less than 0.7% of patients, and 1.9% of patients required ICU care. —Transmission and Prevention: A report by the Center for Disease Control and Prevention of the COVID-19 outbreak that ocurred on the USS Theodore Roosevelt showed that 60% of respondents exhibited evidence of exposure to SARS-CoV-2 via positive neutralizing antibody assay, ageusia and anosmia were the symptoms most associated with current or previous infection among crew members, and 212 (90.2%) of the 235 respondents that reported a previous positive COVID-19 test via RT-PCR tested positive for neutralizing antibodies. —Management: Guidelines for managing COVID-19 patients includes: Diagnosis, treatment, and prevention of venous thromboembolic disease and Donor and candidate selection for transplants. —Diagnosis and Treatment: - A retrospective study found that patients with diminished ovarian reserve who delayed in vitro fertilization treatment (to 90 -180 days from their first visit) had similar live birth rates transfer than those that did not suggesting that delaying IVF in these patients does not affect live birth rate. This data can facilitate decision-making concerning treatment delays and disruptions in this population during the COVID-19 pandemic. - A meta-analysis of 22 studies assessing the diagnostic efficiency of anti-SARS-CoV-2 IgG and IgM tests found specificities of 99% in both tests and sentisivities of 85% and 74% for IgG and IgM respectively. - Analysis of SARS-CoV-2 IgM and total antibody levels in 192 patients with severe or mild COVID-19 found no statistically significant differences between mild and severe COVID-19 cases within 6 days of disease onset; however, after day 6, severe cases exhibited higher IgM and a higher overall positivity rate for total antibody titers than that of mild cases. Further, 12/35 mild cases never exhibited IgM positivity and 5/35 remained negative for total antibody titers highlighting the possible limitations in antibody testing of patients with mild COVID-19

5 MIN2 w ago
Comments
June 25, 2020

June 23, 2020

On today's episode we discuss: —Climate: A study conducted by the Center for Disease Control and Prevention of 2,402 Americans in May found widespread support of the implementation of public health orders such as stay-at-home orders, use of face coverings, and business closures, in response to the COVID-19 pandemic. —Epidemiology: A cross-sectional study in Indianapolis found that 3.1% of 2,953 asymptomatic adults tested positive for SARS-CoV-2 by nasopharyngeal swab testing. Of the 81 SARS-CoV-2 positive participants who completed a follow-up interview, 71.6% remained asymptomatic at 14 days while the other 28.4% reported one or more symptoms. —Management: A group of researchers in Toronto suggest SARS-CoV-2 disruption of the renin angiotensin aldosterone system (RAAS) leads to an endothelial imbalance that leaves the endothelium susceptible to inflammation, vasoconstriction, platelet activation, and thrombosis thus playing a major role in the disease. —Diagnosis and Treatment: A study of 190 patients found that oropharyngeal/nares swabs and nasopharyngeal swabs had sensitivities of 91.7% and 94.4%, respectively, suggesting that oropharyngeal/nares sampling, which may be more readily available during the COVID-19 pandemic, is an effective alternative to nasopharyngeal swabs in ambulatory settings —Mental Health and Resilience: Psychiatrists and addiction medicine experts from Germany conducted a survey of 2,102 German citizens and found that 34.7% of respondents have consumed “more or much more” alcohol during the pandemic compared to their baseline, and indicated that increased alcohol consumption during this time is associated with lower educational status and increased stress.

6 MIN2 w ago
Comments
June 23, 2020

June 22, 2020

On today's episode we discuss: —Climate: An analysis of the economic impact of COVID-19 on older adults highlights that more than 1/3 of adults 65 years or older live in counties with a high cost of living and increased COVID-19 prevalence demonstrating an overlap between "infection rates and economic insecurities" during COVID-19 with nearly 25% of these adults relying on Social Security benefits that may be insufficient to meet financial needs during a pandemic. The authors encourage employment and economic recovery strategies to take into consideration the older population —Epidemiology: A two-center retrospective study at Wuhan Pulmonary Hospital and Tongji Hospital examining 1,018 COVID-19 patients found that increased interleukin-6 (IL-6) levels (>20 pg/mL; P<0.001) and decreased CD8+ T cell levels (<165 cells/mul; P<0.001) are both independently associated with increased mortality in patients with COVID-19, suggesting that both of these indicators may help clinicians in prognostication and clinical decision making. —Management: A case series of 63 positive end-expiratory pressure (PEEP) titrations performed in 15 patients with COVID-19-related ARDS using electrical impedance tomography (EIT) found that high PEEP were from personalized PEEP at the level of lowest relative alveolar overdistention and collapse, PEEP set was positively correlated to BMI (p< 0.001), and individualized PEEP titration could result in improved clinical outcomes but further research is needed to confirm whether this personalized PEEP titration approach is safe and effective. —Diagnosis and Treatment: A retrospective cohort conducted at Daegu Catholic University School of Medicine in Korea found that 31 COVID-19-positive patients treated with lopinavir-ritonavir had significantly shorter times to negative conversion of viral RNA than 34 COVID-19-positive patients treated with hydroxychloroquine (median, 21 days vs. 28 days; Figure 2); however, time until clinical improvement was not found to be different between these groups.

9 MIN2 w ago
Comments
June 22, 2020

June 18, 2020

On today's episode we discuss: — A cross-sectional study conducted in Indianapolis found that 3.1% of 2,953 adults tested positive for SARS-CoV-2 by nasopharyngeal swab testing. Of the 81 SARS-CoV-2 positive participants who completed a follow-up interview, 71.6% remained asymptomatic at 14 days while the other 28.4% reported one or more symptoms. — A study of 1,353 COVID-19 positive children found the three most common symptoms in this population were fever (21.7%), cough (15.4%), and abnormal breathing (8.1%) with the most severe manifestations, such as intubation or myocarditis, occurring in less than 0.7% of patients, and only 1.9% of patients requiring ICU care. — An event-study model utilizing data from 15 states plus Washington, D.C. that had implemented mandatory masks in public revealed a statistically significant decrease in daily county-level growth rates of COVID-19 after implementation of mask wearing mandates, suggesting that transmission rates of COVID-19 may decrease as more states mandate face masks in public. — Pulmonary specialists describe how utilizing nearby hotels for recovering COVID-19 patients discharged from overwhelmed hospitals may be an effective method to meet surging demands citing this approach’s success in certain Italian hospitals. — A review of the mental health impact of the COVID-19 pandemic could increase the risk for suicidal behaviors. — Healthcare reform recommendations are outlined as the current pandemic could be a rare catalyst for major political shifts toward a more efficient and effective system of care, primarily addressing barriers to paying for services and provider reimbursement.

9 MIN2 w ago
Comments
June 18, 2020

June 16, 2020

On today's episode we discuss: — Molecular structures that may contribute to SARS-CoV-2 pathogenicity. — More evidence for SARS in the urine — Dosing medications in COVID-19 patients

9 MIN3 w ago
Comments
June 16, 2020

June 15, 2020

On this episode we discuss - How COVID-19 are causing delays in care seeking with dire consequences - More data regarding surrounding the issue of testing via RTPCR - Factors contributing to moral distress in healthcare workers

9 MINJUN 17
Comments
June 15, 2020

June 13, 2020

On todays report we discuss: – Who is at risk for acute pulmonary embolisms? – What is the state of clinical trials on COVID-19 therapeutics? – Are some patients regain their sense of smell after recovering from their infection?

6 MINJUN 14
Comments
June 13, 2020

June 11, 2020

On todays report, we discuss –How frontline healthcare providers can mitigate sleep deprivation during this pandemic – The connection between obesity and disease severity – Whether or not we should be using CTs with the nasal swab together to diagnose COVID 19

8 MINJUN 13
Comments
June 11, 2020
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