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Tumor Immunology Round Table

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Tumor Immunology Round Table

Tumor Immunology Round Table

pedro

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Followers
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Plays
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About Us

This podcast aims to present you research articles recently published in the field of immunology and tumor immunology in an journal club format. Disclaimer: the comments provided are strictly personal and do not represent the scientific positions or scientific orientations of the institutions where the authors of this podcast work or have worked in the past. The audio soundtrack is provide by Magnatunes.com. I used the track "Innocent Murmur" from the album "First album", produced by the progressive jazz band

Latest Episodes

How Alum adjuvant boost antigenic response

In this edition, I discuss the recent paper of Kool et al submitted to JEM, and where the authors evaluate the effect of aluminum adjuvant in antigen response. The authors found thad adjuvant mix results in the mobilization of phagocytes and monocytes to the peritoneal cavity upon i.p. injection of antigen, boosting antigen specific T cell response in the draining lymph nodes The most important observation found by authors was that inflammatory monocytes mobilized by adjuvant differentiate into matured dendritic cells and such cells are key elements in the antigen T cell response. A great reading... For reference please check the mouse lymph node localizations on this link. See you soon and have a nice listening

21 MIN2008 JUL 21
Comments
How Alum adjuvant boost antigenic response

Efective anti-cancer immunotherapy with CD4 T cell clone

In this edition, I describe the manuscript published by the group of Cassian Yee to the New England Journal of Medicine entitled "Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1", that can be found in the volume 358 page 2698, of 2008 year series.

44 s2008 JUL 1
Comments
Efective anti-cancer immunotherapy with CD4 T cell clone

Anti-tumor role of {gamma}{delta} T cells in expontaneous prostate tumors

In this podcast I will describe a recent manuscript submitted by Liu et al to journal of Immunology 2008; 108:6044 , where {gamma}{delta} T cell knock-out mice were evaluated under situation of expontaneous prostate cancer (crossed with TRAMP mice) and in addition {gamma}{delta} T cells were also used in adoptive therapy settings against established tumors and metastatic disease. The authors show that under the experimental design setting that {gamma}{delta} T cells play a certain role in controlling tumor growth, by reducing the tumor burden and aggressiveness. See you next time

10 MIN2008 MAY 28
Comments
Anti-tumor role of {gamma}{delta} T cells in expontaneous prostate tumors

NKG2D mediated tumor immunity

Hi folks, Today I will do a short overview of a major manuscript published recently in journal immunity that presents data concerning the evaluation of NKG2D knock-out mice in the context of expontaneous tumor development. The format of the podcast has changed to fit in my time constrains. Let me know what do you think. See you soon, and thanks for listening

8 MIN2008 MAY 8
Comments
NKG2D mediated tumor immunity

N-acetyllactosamine (lacNAC) reverts human TIL anergy ex vivo.

Hello In this edition of the podcast I will discuss a paper published by Demotte and collaborators published this year in the journal Immunity "Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes" vol 28, pag 414 of April 2008. In this paper the authors show that LacNAC can compete for galectin-3 binding freeing TCR from TIL to colocalize with CD8 and allow the recovery of efector functional on ex vivo freshly isolated TIL from ovarian cancer and gastric cancer. See you next time.

35 MIN2008 APR 21
Comments
N-acetyllactosamine (lacNAC) reverts human TIL anergy ex vivo.

A diversified memory repertoire from a single naive T cell

Hello In this edition of the podcast I will discuss a paper published by Stemberger and collaborators in the journal Immunity called "A single naive CD8+ T cells precursor can develop into diverse effector and memory subset" vol 27, pag 987 of December 2007. In this very interesting paper the authors redraw the concepts of memory T cells differentiation from naive T cells, developping a successfull model of transfer of an single naive T cell precursor. The paper shows that this single antigen specific naive T cell precursor can give rise to an diversified memory T cell responses including all subsets (central memory (CD62L positive, CD127 posit) and effector memory (CD62L negative, CD127 positive) T cells) upon antigen challenge. Importantly the kind of memory responses were equivalent in frequency to the ones generated by the host mice (containing a normal size naive pool of antigen specific T cells) against an antigenic protein. See you next time. PS: The audio has "clicks" artifacts that I don't know the origin. I apologize for that.

21 MIN2008 MAR 5
Comments
A diversified memory repertoire from a single naive T cell

Immune pressure results in mutation of DRIP derived epitope in SIV

Hello Welcome to the first edition of the Tumor Immunology Round Table podcast. In this edition I present you an very interesting and novel finding recently published in Journal of Experimental Medicine by Maness et al: the immune system induces the mutation by the SIV of an DRIP (defective ribosomal product) that is immunogenic and induces strong dominant responses in monkeys infected with SIV. The DRIP derives from a alternative reading frame of the gene env. The mutation specifically target the immunogenic peptide presented my the rhesus macaques haplotype mamu-B*17, as it doesn't affect the env sequence (sinonimous mutation). The mutation renders the peptide with much lower affinity than the wild type peptide and therefore the virus escape the immunological control. That's a great example of immunological editing of virus and the conclusions can be easily extrapolated to cancer immune editing.

23 MIN2008 FEB 20
Comments
Immune pressure results in mutation of DRIP derived epitope in SIV

Immune pressure results in mutation of DRIP derived epitope in SIV

Hello Welcome to the first edition of the Tumor Immunology Round Table podcast. In this edition I present you an very interesting and novel finding recently published in Journal of Experimental Medicine by Maness et al: the immune system induces the mutation by the SIV of an DRIP (defective ribosomal product) that is immunogenic and induces strong dominant responses in monkeys infected with SIV. The DRIP derives from a alternative reading frame of the gene env. The mutation specifically target the immunogenic peptide presented my the rhesus macaques haplotype mamu-B*17, as it doesn't affect the env sequence (sinonimous mutation). The mutation renders the peptide with much lower affinity than the wild type peptide and therefore the virus escape the immunological control. That's a great example of immunological editing of virus and the conclusions can be easily extrapolated to cancer immune editing.

23 MIN2008 FEB 20
Comments
Immune pressure results in mutation of DRIP derived epitope in SIV
the END

Latest Episodes

How Alum adjuvant boost antigenic response

In this edition, I discuss the recent paper of Kool et al submitted to JEM, and where the authors evaluate the effect of aluminum adjuvant in antigen response. The authors found thad adjuvant mix results in the mobilization of phagocytes and monocytes to the peritoneal cavity upon i.p. injection of antigen, boosting antigen specific T cell response in the draining lymph nodes The most important observation found by authors was that inflammatory monocytes mobilized by adjuvant differentiate into matured dendritic cells and such cells are key elements in the antigen T cell response. A great reading... For reference please check the mouse lymph node localizations on this link. See you soon and have a nice listening

21 MIN2008 JUL 21
Comments
How Alum adjuvant boost antigenic response

Efective anti-cancer immunotherapy with CD4 T cell clone

In this edition, I describe the manuscript published by the group of Cassian Yee to the New England Journal of Medicine entitled "Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1", that can be found in the volume 358 page 2698, of 2008 year series.

44 s2008 JUL 1
Comments
Efective anti-cancer immunotherapy with CD4 T cell clone

Anti-tumor role of {gamma}{delta} T cells in expontaneous prostate tumors

In this podcast I will describe a recent manuscript submitted by Liu et al to journal of Immunology 2008; 108:6044 , where {gamma}{delta} T cell knock-out mice were evaluated under situation of expontaneous prostate cancer (crossed with TRAMP mice) and in addition {gamma}{delta} T cells were also used in adoptive therapy settings against established tumors and metastatic disease. The authors show that under the experimental design setting that {gamma}{delta} T cells play a certain role in controlling tumor growth, by reducing the tumor burden and aggressiveness. See you next time

10 MIN2008 MAY 28
Comments
Anti-tumor role of {gamma}{delta} T cells in expontaneous prostate tumors

NKG2D mediated tumor immunity

Hi folks, Today I will do a short overview of a major manuscript published recently in journal immunity that presents data concerning the evaluation of NKG2D knock-out mice in the context of expontaneous tumor development. The format of the podcast has changed to fit in my time constrains. Let me know what do you think. See you soon, and thanks for listening

8 MIN2008 MAY 8
Comments
NKG2D mediated tumor immunity

N-acetyllactosamine (lacNAC) reverts human TIL anergy ex vivo.

Hello In this edition of the podcast I will discuss a paper published by Demotte and collaborators published this year in the journal Immunity "Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes" vol 28, pag 414 of April 2008. In this paper the authors show that LacNAC can compete for galectin-3 binding freeing TCR from TIL to colocalize with CD8 and allow the recovery of efector functional on ex vivo freshly isolated TIL from ovarian cancer and gastric cancer. See you next time.

35 MIN2008 APR 21
Comments
N-acetyllactosamine (lacNAC) reverts human TIL anergy ex vivo.

A diversified memory repertoire from a single naive T cell

Hello In this edition of the podcast I will discuss a paper published by Stemberger and collaborators in the journal Immunity called "A single naive CD8+ T cells precursor can develop into diverse effector and memory subset" vol 27, pag 987 of December 2007. In this very interesting paper the authors redraw the concepts of memory T cells differentiation from naive T cells, developping a successfull model of transfer of an single naive T cell precursor. The paper shows that this single antigen specific naive T cell precursor can give rise to an diversified memory T cell responses including all subsets (central memory (CD62L positive, CD127 posit) and effector memory (CD62L negative, CD127 positive) T cells) upon antigen challenge. Importantly the kind of memory responses were equivalent in frequency to the ones generated by the host mice (containing a normal size naive pool of antigen specific T cells) against an antigenic protein. See you next time. PS: The audio has "clicks" artifacts that I don't know the origin. I apologize for that.

21 MIN2008 MAR 5
Comments
A diversified memory repertoire from a single naive T cell

Immune pressure results in mutation of DRIP derived epitope in SIV

Hello Welcome to the first edition of the Tumor Immunology Round Table podcast. In this edition I present you an very interesting and novel finding recently published in Journal of Experimental Medicine by Maness et al: the immune system induces the mutation by the SIV of an DRIP (defective ribosomal product) that is immunogenic and induces strong dominant responses in monkeys infected with SIV. The DRIP derives from a alternative reading frame of the gene env. The mutation specifically target the immunogenic peptide presented my the rhesus macaques haplotype mamu-B*17, as it doesn't affect the env sequence (sinonimous mutation). The mutation renders the peptide with much lower affinity than the wild type peptide and therefore the virus escape the immunological control. That's a great example of immunological editing of virus and the conclusions can be easily extrapolated to cancer immune editing.

23 MIN2008 FEB 20
Comments
Immune pressure results in mutation of DRIP derived epitope in SIV

Immune pressure results in mutation of DRIP derived epitope in SIV

Hello Welcome to the first edition of the Tumor Immunology Round Table podcast. In this edition I present you an very interesting and novel finding recently published in Journal of Experimental Medicine by Maness et al: the immune system induces the mutation by the SIV of an DRIP (defective ribosomal product) that is immunogenic and induces strong dominant responses in monkeys infected with SIV. The DRIP derives from a alternative reading frame of the gene env. The mutation specifically target the immunogenic peptide presented my the rhesus macaques haplotype mamu-B*17, as it doesn't affect the env sequence (sinonimous mutation). The mutation renders the peptide with much lower affinity than the wild type peptide and therefore the virus escape the immunological control. That's a great example of immunological editing of virus and the conclusions can be easily extrapolated to cancer immune editing.

23 MIN2008 FEB 20
Comments
Immune pressure results in mutation of DRIP derived epitope in SIV
the END
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