Scientist Albert Hoffman’s synthesis of LSD-25 in 1938 was hailed as a miracle psychopharmaceutical throughout the 1950s and studied by Harvard University and others for use in psychiatric treatment. Grim’s candid investigation of the controversial chemical includes CIA, counter-culture, and medical interest and contention through the present. Explores Native-American shamanism, psylocibin, and ayahuasca. And the intellectuals and institutions behind its renaissance.