In this episode, Gianluca and Jared discuss the neurobiology of predictive processing, the role of dopamine in reward signalling, satisfaction, and human desire. They also touch on the relation of reward to reinforcement learning and artificial intelligence. The podcast then shifts to discuss the clinical manifestations of the predictive brain, including the computational psychiatry of depression, autism-spectrum-disorder, and schizophrenia, and how top-down prediction, and precision-weighted prediction error explain many important features of these conditions.